Gene frequencies of human platelet alloantigens in Bahraini Arabs
نویسندگان
چکیده
منابع مشابه
Gene frequencies of human platelet alloantigens in Kelantan, Malaysia.
The gene for the ß 3 (GPIIIa) subunit of the integrin α IIb ß 3 (GPIIb-IIIa) present on the platelet membrane contains the platelet antigen alleles (PlA) in a homozygous form (Pl/) or the heterozygous or polymorphic form (Pl/) in humans. This GPIIIa subunit serves as a receptor for adhesive proteins (viz. fi brinogen and von Willebrand factor) and is critical for platelet aggregation. The struc...
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The platelets of 11 patients with Glanzmann's thrombasthenia and their nearest family members were studied for the expression of the platelet-specific alloantigens of the Zw-, Ko- and Bak systems. The strength of the expression of the Zwa antigen was diminished on the platelets of 3 patients, and the antigen was absent from the platelets of the other 8. The platelets of none of the patients rea...
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Neutrophil alloantigens are involved in a variety of clinical conditions including immune neutropenias, transfusion-related acute lung injury (TRALI), refractoriness to granulocyte transfusions and febrile transfusion reactions. In the last decade, considerable progress has been made in the characterization of the implicated antigens. Currently, seven antigens are assigned to five human neutrop...
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Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-1) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors...
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The biallelic platelet-specific Gov antigen system-implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura-is carried by the glycosylphosphatidylinositol (GPI)-linked protein CD109. The recent identification of the human CD109 complementary DNA (cDNA) has allowed the molecular nature of the Gov alleles to be elucidated. By using re...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2007
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.20769